| Timeframe | Title | Duration | Details |
| 11.08.2023 - 04.11.2023 | WWE United States Champion (3x) | 85 days | Matches |
| 16.05.2021 - 18.07.2021 | WWE SmackDown Tag Team Champion (with Dominik Mysterio) | 63 days | Matches |
| 25.11.2019 - 26.12.2019 | WWE United States Champion (2x) | 31 days | Matches |
| 19.05.2019 - 03.06.2019 | WWE United States Champion | 15 days | Matches |
| 04.11.2017 - 03.11.2018 | The Crash Heavyweight Champion | 364 days | Matches |
| 12.06.2016 - 12.06.2016 | DDT Iron Man Heavy Metal Champion (as Rey Mysterio Jr.) | <1 day | Matches |
| 03.10.2015 - 10.04.2016 | Destiny World Champion | 190 days | Matches |
| 10.01.2016 - 17.01.2016 | Lucha Underground Trios Champion (as Rey Mysterio Jr.; with Dragon Azteca Jr. and Prince Puma) | 7 days | Matches |
| 25.07.2011 - 25.07.2011 | WWE Heavyweight Champion (with CM Punk) | <1 day | Matches |
| 20.06.2010 - 18.07.2010 | World Heavyweight Champion (2x) | 28 days | Matches |
| 28.06.2009 - 01.09.2009 | WWE Intercontinental Champion (2x) | 65 days | Matches |
| 05.04.2009 - 07.06.2009 | WWE Intercontinental Champion | 63 days | Matches |
| 02.04.2006 - 23.07.2006 | World Heavyweight Champion | 112 days | Matches |
| 13.12.2005 - 27.12.2005 | WWE Tag Team Champion (4x) (with Batista) | 14 days | Matches |
| 20.02.2005 - 18.04.2005 | WWE Tag Team Champion (3x) (with Eddie Guerrero) | 57 days | Matches |
| 07.12.2004 - 11.01.2005 | WWE Tag Team Champion (2x) (with Rob Van Dam) | 35 days | Matches |
| 15.06.2004 - 27.07.2004 | WWE Cruiserweight Champion (3x) | 42 days | Matches |
| 30.12.2003 - 15.02.2004 | WWE Cruiserweight Champion (2x) | 47 days | Matches |
| 03.06.2003 - 23.09.2003 | WWE Cruiserweight Champion | 112 days | Matches |
| 05.11.2002 - 17.11.2002 | WWE Tag Team Champion (with Edge) | 12 days | Matches |
| 06.01.2002 - 06.04.2002 | WWC Junior Heavyweight Champion (as Rey Misterio Jr.) | 90 days | Matches |
| 26.03.2001 - 26.03.2001 | WCW Cruiserweight Tag Team Champion (as Rey Mysterio Jr.; with Billy Kidman) | <1 day | Matches |
| 14.08.2000 - 18.09.2000 | WCW World Tag Team Champion (3x) (as Rey Mysterio Jr.; with Juventud Guerrera as The Filthy Animals) | 35 days | Matches |
| 18.10.1999 - 24.10.1999 | WCW World Tag Team Champion (2x) (as Rey Mysterio Jr.; with Konnan as The Filthy Animals) | 6 days | Matches |
| 26.04.1999 - 19.08.1999 | WCW World Cruiserweight Champion (6x) (as Rey Mysterio Jr.) | 115 days | Matches |
| 29.03.1999 - 09.05.1999 | WCW World Tag Team Champion (as Rey Mysterio Jr.; with Kidman) | 41 days | Matches |
| 15.03.1999 - 19.04.1999 | WCW World Cruiserweight Champion (5x) (as Rey Mysterio Jr.) | 35 days | Matches |
| 12.07.1998 - 13.07.1998 | WCW World Cruiserweight Champion (4x) (as Rey Mysterio Jr.) | 1 day | Matches |
| 15.01.1998 - 24.01.1998 | WCW World Cruiserweight Champion (3x) (as Rey Mysterio Jr.) | 9 days | Matches |
| 26.10.1997 - 10.11.1997 | WCW World Cruiserweight Champion (2x) (as Rey Misterio Jr.) | 15 days | Matches |
| 20.07.1996 - 21.02.1997 | WWA World Welterweight Champion (3x) (as Rey Misterio Jr.) | 216 days | Matches |
| 16.06.1995 - xx.xx.1996 | WWA World Lightweight Champion (3x) (as Rey Misterio Jr.) | ? | Matches |
| 08.07.1996 - 27.10.1996 | WCW World Cruiserweight Champion (as Rey Misterio Jr.) | 111 days | Matches |
| 29.09.1995 - 28.04.1996 | WWA World Welterweight Champion (2x) (as Rey Misterio Jr.) | 212 days | Matches |
| 22.09.1995 - 28.09.1995 | WWA World Welterweight Champion (as Rey Misterio Jr.) | 6 days | Matches |
| 15.04.1995 - 06.07.1995 | Mexican National Trios Champion (as Rey Misterio Jr.; with Octagon and Super Muneco) | 82 days | Matches |
| xx.xx.1995 - 02.03.1995 | WWA World Tag Team Champion (as Rey Misterio Jr.; with Rey Misterio) | ? | Matches |
| 30.11.1994 - 02.03.1995 | WWA World Lightweight Champion (2x) (as Rey Misterio Jr.) | 92 days | Matches |
| xx.xx.1993 - 15.10.1993 | WWA World Lightweight Champion (as Rey Misterio Jr.) | ? | Matches |
| 28.10.1992 - 26.02.1993 | Mexican National Welterweight Champion (as Rey Misterio Jr.) | 121 days | Matches |
| Title | Duration |
| DDT Iron Man Heavy Metal Championship | <1 day |
| Destiny World Championship | 190 days |
| Lucha Underground Trios Championship | 7 days |
| Mexican National Trios Championship | 82 days |
| Mexican National Welterweight Championship | 121 days |
| The Crash Heavyweight Championship | 364 days |
| WCW Cruiserweight Tag Team Championship | <1 day |
| WCW World Cruiserweight Championship (6x) | 286 days |
| WCW World Tag Team Championship (3x) | 82 days |
| World Heavyweight Championship (2x) | 140 days |
| WWA World Lightweight Championship (3x) | 92 (+ ?) days |
| WWA World Tag Team Championship | 0 (+ ?) days |
| WWA World Welterweight Championship (3x) | 434 days |
| WWC Junior Heavyweight Championship | 90 days |
| WWE Championship | <1 day |
| WWE Cruiserweight Championship (3x) | 201 days |
| WWE Intercontinental Championship (2x) | 128 days |
| WWE Tag Team Championship | 63 days |
| WWE United States Championship (3x) | 131 days |
| WWE World Tag Team Championship (4x) | 118 days |
